RESUMO
Background: Exposure to high levels of aluminium (Al) leads to neurotoxicity. Hippocampus is one of the preferred sites of aluminium accumulation. Nevertheless, the role of Al in Alzheimer’s disease (AD) remains controversial and there is little proof directly interlinking Al to AD. Aims: The present study was undertaken to find out the occurrence of AD pathogenesis in Hippocampus under moderate aluminium exposure in rats. Materials and Methods: Adult rats were divided into control (C) and aluminium treated (E) groups having eight animal each. The rats in group E were exposed to aluminium 4.2 mg/kg body weight for three months with due approval from Institute Animal Ethics Committee. The hippocampus was processed for histopathological and electron microscopy observation. Results: Moderate Al intake produces significant reduction in the count of Pyramidal cells in hippocampus identified by shrunken cells as well as pyknosis in cell bodies. The differences between the cell numbers in all groups were found to be statistically significant (P < 0.05). Cornu Ammonis (CA) exhibited significantly reduced nissl bodies with a marked reduction in neuronal cell loss. Neurofibrillary tangle and plaques were not seen in the given dose of Al exposure. Electron microscopy from experimental group showed that the majority of neurons were disintegrating, the nuclear membrane has ruptured, and nucleoli appeared significantly distorted. The chromatin condensed and the mitochondria had disintegrated. Many vacuoles and lipofuscin sediment in cytoplasm, as compared to the control group noted. Conclusion: Present data demonstrated that moderate chronic aluminium exposure 4.2mg/kg body weight induced neurodegeneration in hippocampus but not significant for Alzheimer’s disease pathogenesis.
RESUMO
Background: Arcuate foramen is a variation in the posterior arch of atlas vertebrae. It is commonly called as Kimmerle’s anomaly, also known as Ponticulus Posticus. It is the product of the complete or incomplete ossification of the posterior atlantooccipital membrane over the vertebral artery groove resulting in the formation of arcuate foramen containing the vertebral artery and the posterior branch of the first cervical spinal nerve. Aims: The aim of the present study was to identify the percentage of incidence of arcuate foramen in the atlas and its clinical important. Materials and Methods: The study was conducted in the Department of Anatomy, Katihar Medical College, Katihar, India with 32 adult dried atlas vertebrae. Results: We found four (12.5%) atlas with arcuate foramen. One atlas having complete arcuate foramen and three having partial complete arcuate foramen. Conclusion: Awareness of this type of variation is very important for neurosurgeons and radiologist during their clinical practice. The presence of the arcuate foramen would also complicate screw placement during surgery. Clinical prescreening for signs of vertebrobasilar insufficiency is important for chiropractic and manual therapies.
RESUMO
A tendinous origin and fleshy insertion of palmaris longus muscle was observed in the left forearm during routine dissection which was performed on adult male cadaver in the department of Anatomy, Dr. Rajendra Prasad Government Medical College. It was having long tendinous origin from the medial epicondyle of the humerus and the surrounding deep fascia. It was fusiform at the lower middle of the forearm. The fleshy muscular insertion was noted to the flexor retinaculum and few muscular fibers interdigitate with flexor carpi ulnaris muscle and palmar aponeurosis. The length of tendon was 19 inches and fleshy muscular length was 11inches. Themedian nerve and ulnar nervewas covered by this fleshy insertion. This palmaris longus variation is helpful for the surgeon and the radiologist, orthopaedic, plastic surgeon during any diagnosis of the forearm because this fleshy part of muscle can compress the median nerve and ulnar nerve or it can be mistaken as a tumor or ganglion during radiological or clinical examination.